The safest pigments for aesthetic keratopigmentation

Unmatched safety – Designed specifically for aesthetic use

NEORIS pigments are the only pigments developed exclusively for aesthetic keratopigmentation. Unlike other products, they have been specifically formulated to meet the highest safety standards for corneal application.

To ensure their exceptional safety, NEORIS pigments have undergone rigorous evaluation by Eurofins, a globally recognized expert in medical device testing. Under the supervision of toxicologists, their assessment confirmed that NEORIS pigments pose no risk to users.

Why NEORIS pigments are the safest choice?

✅ Sterile – For optimal safety

✅ Made of stable, non-toxic ingredients – Free from harmful substances found in other pigments, including:

  • Unstable pigments that change color over time
  • Magnetic pigments highly reactive in MRI
  • Nanoparticles which can be cytotoxic
  • Preservatives & pH regulators which can be corrosive

✅ Fully compatible with the cornea – Preserving endothelial cells.

✅ Manufactured in Switzerland – Under strict GMP and Swissmedic standards.

✅ Packaged in pharmaceutical-grade materials – Free from endocrine-disrupting substances like phthalates.

Safe MRI with NEORIS Pigments

Recent research published in Cornea, led by Dr. Alió, a world-renowned keratopigmentation expert, revealed a major safety concern with CE-marked pigments:

  • After MRI (Magnetic Resonance Imaging) exposure, the pigment turned red/orange.
  • The patient experienced pain during the MRI.

This reaction was traced to the presence of magnetic iron oxide (CI77499, also known as magnetite)—a component found in many CE-marked pigments but never used in NEORIS pigments.

Read the study

Preserving endothelial cells – A critical factor in long-term safety

Protecting endothelial cells is crucial in any corneal procedure, as their loss can lead to serious long-term consequences for vision. When endothelial cells are significantly reduced, color touch-ups become impossible.

A recent study comparing endothelial cell loss after keratopigmentation showed:

  • ✅ NEORIS pigments result in far lower cell loss than even common and widely accepted eye surgeries such as LASIK and SMILE.
  • ❌ CE-marked pigments cause significantly more endothelial cell loss than eye surgeries such as LASIK and SMILE - posing a potential long-term risk to vision.


Why? Many unstable and controversial ingredients commonly used in CE-marked pigments were intentionally excluded from NEORIS formulations.


Choosing the right pigment for the right indication is essential. CE-marked pigments are designed for therapeutic use, while NEORIS pigments are designed specifically for aesthetic safety.

CE-Marked Pigments: A Higher Risk for Aesthetic Keratopigmentation?

Many CE-marked pigments were never designed for aesthetic keratopigmentation. Because of their medical classification, their benefit/risk ratio is assessed based on a therapeutic need—meaning some risk is accepted in exchange for a medical benefit.

However, for purely aesthetic procedures, safety must be absolute.

Using CE-Marked Pigments for Aesthetic Keratopigmentation Involves Risks:

  • ❌ Higher risk of endothelial cell loss – Potential long-term vision impact.
  • ❌ Pain and intense discoloration after MRI – Caused by unstable pigments.
  • ❌ Legal and insurance concerns – Using a CE-marked medical pigment outside its intended purpose does not provide additional protection and may expose professionals to liability.


NEORIS ensures full compliance with general product safety standard, which states that aesthetic products must present zero risk to users. To meet this standard, Eurofins toxicologists have thoroughly evaluated NEORIS pigments, confirming their safety.

When it comes to safety, compromise is not an option. Trust NEORIS for the safest, most stable pigments available for aesthetic keratopigmentation.

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